Prostatic adenocarcinoma

Malignant glands and tumor cells with Gleason’s pattern 3,4 and 5 infiltrating through the prostate

Malignant glands lack basal cell layer and show loss of staining with basal cell marker (34βE12 and p63)

Prostate core biopsy with Gleason’s Pattern 4 glomeruloid structure and perineural invasion